开始日期: 2024-01-12

　　课时安排: 2周专业预修与在线科研+10天面授科研+5周在线论文指导

　　适合人群

　　适合年级 (Grade): 高中生/大学生

　　适合专业 (Major): 食品科学与技术、膳食营养学、运动营养学、临床营养学、应用生物学相关专业的学生;对希望保持膳食平衡，拥抱健康生活感兴趣的学生;学生需要具备生物、化学基础

　　导师介绍

　　Sharon

　　哥伦比亚大学 Columbia University营养学家&终身教授

　　Sharon导师是美国知名营养学家，哥伦比亚大学的终身正教授，营养研究所课程负责人、营养学硕士课程负责人、美国医学中心人类营养研究所副教授。多年来在教学方面成果丰厚，曾获得年度高级教师学者提名、2010年荣获哥伦比亚大学“杰出教学奖”(Faculty Presidential Teaching award)、2020年入选“高级教职学者奖”(Provost Senior Teaching Faculty)。 Professor Sharon is a distinguished nutritionist in the United States. She is a tenured full professor at Columbia University, course director of the Nutrition Institute, Course director of the Master's Program in Nutrition, and associate professor at the Institute of Human Nutrition at the American Medical Center. Over the years, he has made great achievements in teaching, She has been nominated for Senior Faculty Scholar of the Year, and is the recipient of Columbia's Faculty Presidential Teaching award in 2010 and Provost Senior Teaching Award in 2020 Faculty).

　　她拥有哥伦比亚大学营养学博士学位，在哥伦比亚大学先后开设了超过20门营养学课程，内容跨越女性与体重的生物化学与生理学研究、肥胖症的病因与防治等。She holds a Ph.D. in nutrition from Columbia University, where she has taught more than 20 courses in nutrition, ranging from biochemical and physiological studies of women and weight to the causes and prevention of obesity

　　任职学校

　　哥伦比亚大学，正式名称为纽约市哥伦比亚大学(Columbia University in the City of New York)，坐落于美国纽约曼哈顿上城区晨边高地，是一所世界顶尖私立研究型大学、美国大学协会(Association of American Universities)十四所创始院校之一，也是常春藤盟校(Ivy League)之一 。2022年U.S. News世界大学排名第6名。

　　项目背景

　　营养学是一门颇具幸福感的学科，但主要来取决于你的选择，其本质是本能和健康之间的博弈。营养素和细胞的交互，影响了我们的身体状态,所以选择有益的食物，就像对身体做长期定投，收益可观。强调摄入营养素的功能和时机，改善亚健康状态，在疾病之前未雨绸缪，是营养学的核心目标，而七大营养素则是基础。随着基因组学的诞生，让原有的认知边界被逐渐突破和扩展，人类已经迈入“后基因组时代”。营养学紧随其后，与生物化学紧密结合——从细胞代谢和分子层级研究与基因之间的关系和影响，延展出分子营养学(也称营养基因组学)，使个性化营养需求得以实现，也对药物研发、疾病管理有重要指导意义。

　　项目介绍

　　本课程的亮点在于：在基础营养学基础之上加入了营养素对基因表达的影响，旨在了解营养素在人体内吸收代谢过程、对细胞和器官的影响、以及对基因表达的影响。学生将在分子层面上深入了解健康饮食模式、营养素与健康的重要性。当国民越来越注重健康养生与保健的时代来临，营养学的实际应用价值和前景将会更加明朗和乐观，例如：精准营养服务、个体化疾病预防、临床饮食指导、慢性疾病药物开发等。学生将在项目结束时提交个性化研究项目报告，并进行成果展示。 The highlight of this course is that the influence of nutrients on gene expression (namely the concept of molecular nutrition) is added on the basis of basic nutrition, aiming to understand the absorption and metabolism process of nutrients in human body, the influence on cells and organs, and the influence on gene expression. Students will gain an in-depth understanding of the importance of healthy eating patterns, nutrients and health at the molecular level. When people pay more and more attention to health preservation and health care, the practical application value and prospect of nutrition will be more clear and optimistic, such as: precise nutrition services, individualized disease prevention, clinical diet guidance, chronic disease drug development, etc. Students will submit a personalized research project report at the end of the project.

　　项目大纲

　　膳食营养与慢性疾病的关系，健康膳食的概念 Introduction to nutrition and health: how nutrition affects so many chronic diseases;

　　食物与营养的消化和吸收：消化系统对人体各个器官系统的影响 Digestion and absorption of food and nutrients: how our gastrointestinal tract sets the stage for the health of every organ system;

　　宏量营养素(碳水化合物、蛋白质、脂肪)与健康的影响 Carbohydrates, protein and fats and health: how the macronutrients can help or hurt our health;

　　细胞营养稳衡，增值和凋亡，碳水化合物对基因表达的调节 Cell nutrition balance, cell proliferation and apoptosis

　　蛋白水解在细胞中基因中的表达，氨基酸依赖的转录调控 Roles in gene expression and proteolysis, Amino acid-dependent transcriptional regulation in cells ;

　　微量营养素(矿物质、维生素)与健康的影响 Micronutrients and health: why something we need in such small amounts have a major effect on our health;

　　维生素基因表达的调节，功效与作用 The regulation of gene expression by vitamins, the efficacy and role of vitamins;

　　食欲与能量代谢平衡：为何保持健康体重会这么困难? Regulation of Appetite and Energy Balance：why maintaining a healthful weight is so challenging;

　　治疗和特殊饮食-坚持的好处，风险和挑战 Therapeutic and Special Diets - Benefits, Risks, and Challenges to Adherence;

　　哺乳动物雷帕霉素靶蛋白mTOR及对癌症的影响 The impact of mTOR in cancer

　　项目回顾与成果展示 Program review and presentation

　　论文辅导 Project deliverable tutoring

　　项目收获

　　2周专业预修与在线科研+10天面授科研+5周在线论文指导

　　项目报告

　　优秀学员获主导师Reference Letter

　　EI/CPCI/Scopus/ProQuest/Crossref/EBSCO或同等级别索引国际会议全文投递与发表指导(可用于申请)

　　结业证书

　　成绩单